Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli
نویسندگان
چکیده
منابع مشابه
Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli
To which extent can optimality principles describe the operation of metabolic networks? By explicitly considering experimental errors and in silico alternate optima in flux balance analysis, we systematically evaluate the capacity of 11 objective functions combined with eight adjustable constraints to predict (13)C-determined in vivo fluxes in Escherichia coli under six environmental conditions...
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ژورنال
عنوان ژورنال: Molecular Systems Biology
سال: 2007
ISSN: 1744-4292,1744-4292
DOI: 10.1038/msb4100162